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Nevertheless, this is also suggestive of an association between a higher expression haplotype of BRCA2 in mutation carriers with lower risk of developing breast cancer.
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Also, we found some evidence of association between a high expression haplotype and lower risk of developing breast cancer among carriers of germline mutations in BRCA2.
In this respect, a correlation between a high expression of MMP-2 and reduced survival in breast cancer patients [ 12] as well as an association of the tumor grade with increased levels of MMP-9 in breast cancer tissue [ 13] was described.
A correlation between the high expression of MMP-13 in breast cancer tissue and a higher rate of distant metastases, poor prognosis and in addition a higher expression of MMP-13 in early stage tumors was shown [ 15, 45].
A relation between higher expression of MMP-2 and -9 and progression of endometrial carcinoma was detected by Di Nezza et al. using in situ hybridization and in situ zymography.
Our results demonstrate that there is a positive correlation between a high CD49f expression and aggressive tumor progression.
However, such a relation between a high TS expression level and a reduced sensitivity to pemetrexed in NSCLC has not been well established.
They observed a significant inverse correlation between a high mammaglobin expression and the most important negative clinical prognostic factor for breast cancer being axillary nodal involvement.
This association between a high AR expression and a good DFS and DMFS was significant for ER-positive tumors (P < 0.0001 and P = 0.0018); however, no association existed between AR expression and prognosis for ER-negative tumors.
For MMP-1, -7, -9, -13 and -14 an association between their high expression and a shortened relapse free survival in breast cancer patients was found [ 15].
A previous study from the same group suggested an association between a higher OSCC miR-146a expression and nodal involvement in patients carrying C polymorphism (rs2910164) [ 34].
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