The connection between FUS function and DNA ligation defects was examined in multiple model systems, including CRISPR/Cas9-mediated FUS knockout (KO) cells, familial ALS patient-derived induced pluripotent stem cells (iPSCs) with FUS mutations, motor neurons differentiated from these patient-derived iPSCs, and spinal cord tissue with FUS pathology from ALS patients.
To further evaluate the relationship between SERT function and impulsive choice, a selective SERT inhibitor, fluoxetine (0, 15, 50 and 150 pmol/side) was microinjected bilaterally into OFC and effects on the delay discounting task determined.
The aim of this study is to elucidate the link between FPC function and the capacity of renal collecting duct epithelial cells to generate normal epithelia.
The relationship between MNS function and self-construals remains highly speculative, however, given the limited and resticted nature of the effect found in the current study.
This study sheds light on the interplay between MECs and their surroundings and points to possible connections between MEC function and pathological processes suggesting a more active role for these cells in maintaining brain function as previously appreciated.
In regard to the link between UPS function and PD, multiple publications have consistently reported greater proteasomal impairment in the presence of aggregated α-synuclein in comparison to its monomeric counterpart [41] [43].
Other studies have reported a possible link between CFTR function and essential FA utilization [3], [22] but have focused on various models of epithelial cells other than intestinal cells.
Such a potential relationship between TLR function and airway Mp may be particularly relevant in light of the findings by Kormann et al. that polymorphic variants of TLRs 1, 2, and 6 contribute to susceptibility and resistance to asthma in children [59].
In line with our previous work and considering the possible interaction between CFTR function and FA homeostasis, we carried out studies to examine the impact of CFTR depletion on FA uptake, composition and metabolism in the intestinal Caco-2/15 cell line.
Other studies have shown the link between DCA function and hypoxia.
