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Hence, we can only join Singer's warning that rapid and large volume loads may lead to iatrogenic fluid overload and that it would be more sensible to give guidelines as to when to use more sophisticated hemodynamic monitoring to better titrate fluid input, rather than 'react post-drowning' [ 33].
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Indeed, the issue of skilling up physicians across settings, or at least increasing access to specialist palliative expertise, is an important challenge and intensivists like Andrew acknowledge that: "some of us are better at titrating than others".
In addition, a RCT carried out by Green and colleagues showed that titrating ICS treatment based on sputum eosinophilia led to better asthma control compared to titrating treatment based on standard asthma guidelines in adults without a significant difference in corticosteroid usage [ 13].
For example, one first tests whether a ventilation protocol (either high volume or low volume) is better than allowing clinicians to titrate according to clinical judgement.
Through these analyses of different Tanner stages, we are better able to set and titrate the basal insulin dose as provided via CSII among type 1 diabetic children in Taiwan.
7, 8 The exenatide twice daily dose can be increased once, whereas liraglutide may be titrated upward twice if needed to achieve better glycemic control.
Titrated dosing and dosing in the fed state were generally better tolerated.
Basal insulin was inadequately titrated in the two studies in which glycemic control was better with premixed compared with basal insulin, as HbA1c at the end of the studies in the basal insulin arm averaged 8.1% (65 mmol/mol) (13) and 7.4% (57 mmol/mol) (13).
We have performed additional ITC experiments where Cpx(26-83) was titrated over a sample of SC 60 containing 3.0 equivalents of CpxI(1-134) to better saturate the binding site.
Indeed, giving patients responsibility to titrate medications themselves is a solution that may sidestep the issue of therapeutic inertia and may thus achieve better BP control than usual care [ 30].
The Steps (Study of Neurontin: Titrate to Effect, Profile of Safety) trial on gabapentin was different.
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