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Trials involving tocilizumab have shown decreased disease activity and better remission rates (category A) [ 44– 44].
Patients having NPM1 mutation in the absence of a FLT3-ITD mutation have better remission rate and overall survival rate.
Scaling score Attarzadeh found no evidence for better remission of scaling with topical clotrimazole use (MD -0.11, 95% CI -0.29 to 0.07) (Analysis 15.3).
In another randomized trial, combination therapy with methotrexate, sulfasalazine, and hydroxychloroquine resulted in better remission rates than single treatment in early RA (category A) [ 40].
Higher doses of systemic glucocorticoids with slow titrations and longer durations are associated with better remission rates and a reduced prevalence of glucocorticoid-dependent ABPA [ 66].
Inclusion of novel agents (thalidomide, portezomib or lenalidomide) in the induction regimens prior to stem cell harvest and transplantation has allowed to achieve better remission quality prior to and after autologous SCT and to reduce treatment‐related mortality.
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Therefore, new studies should focus on new and better remission-induction and consolidation regimens.
It was noted that patients who developed subclinical hypothyroidism had a statistically significant better objective remission rate of 28.3% as compared to 3.3% remission rate in euthyroid patients (P < 0.001) [ 23].
These authors also found a much better tumor remission rate in the groups with early application due to a limited half-life of human lymphocytes in the SCID mouse, a smaller workload for the cytotoxic T-cells and an increased penetration in smaller tumors.
Interestingly, within the same tumours analyses on pre- and post-fine-needle aspirates did not show important changes within genetic profiles; however, an immune response signature present pre-treatment was associated with better prognosis: complete remission (CR), partial remission (PR) and stable disease SD versus progressive disease PD.
We also observed that CCL-deficient dogs had better limb functional remission when osteophyte growth and joint effusion size were minimal.
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