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Newer tests (Prosigna, EndoPredict, Breast Cancer Index) appear to possess better prognostic value for late recurrences while also remaining predictive of early relapse.
Furthermore, CXCR4 expression was identified as an independent prognostic factor for OS, and combining TNM stage with CXCR4 expression showed a better prognostic value for OS in both sets.
The novel parameter asphericity of pretherapeutic FDG uptake seems to provide a better prognostic value for PFS and OAS in NCSLC than SUV, metabolic tumor volume, total lesion glycolysis or the previously described shape feature, solidity.
Consistently, we observed a significant correlation between MyD88 expression and p-Akt levels in a cohort of HCC patients, and found that the combination of these two parameters have better prognostic value for HCC patients.
The novel parameter asphericity of pretherapeutic FDG uptake seems to provide better prognostic value for PFS and OAS in NCSLC compared to SUV, metabolic tumor volume, total lesion glycolysis and solidity.
Interestingly, although our results revealed that elevated preoperative serum CEA level had a better prognostic value for the patients with stages I-II than the corresponding tissue SNCG level, SNCG levels predict the poor clinical outcome better than CEA level for patients with stages III-IV.
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In 2009 Delgado et al. performed an interesting trial with the aim to evaluate the GFR burden on b2m prognostic value in a cohort of 450 subjects affected by chronic lymphocytic leukaemia; they used a multivariate analysis method displaying a significantly better prognostic value of this marker adjusting the value for the GFR [ 53].
However, after 3 years, we observed an obvious drop in the proportion of CIN2+/CIN3+ patients positive for HPV at triage in the Proofer group, indicating that in the NCCSP, hrHPV DNA detection methods had a better prognostic value over time for CIN2+ than the method detecting only the mRNA of five hrHPV types.
Moreover, high TYRP1/S100B was of better prognostic value (lower P-value) for OS than Breslow thickness and ulceration.
The model with the BCL2/ FOS signature was better fitting (likelihood = 90.35) than the model with ESR1/ ERα alone (likelihood = 109.28; P < 10-4) or with only BCL2 (likelihood = 102.64; P = 0.0005) or FOS (likelihood = 114.47; P < 10-4), demonsthating that our two-gene signature has a better prognostic value than ESR1/ ERα alone for RFS.
H-FABP seems to have better diagnostic accuracy and better prognostic value compared with cTn and BNP in cases of PE.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com