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The WPS appeared to have a better prognostic performance than the REMS system.
Presepsin appears to be the most promising new biomarker for early diagnosis of sepsis and better prognostic performance than procalcitonin.
Presepsin is an early marker of mortality, independently of clinical risk factors, with better prognostic performance than PCT.
The meta-signature, on the other hand, accommodated such heterogeneity and achieved comparable or better prognostic performance when compared with the individual signatures.
The performance of soluble triggering receptor expressed on myeloid cells-I (sTREM-1), soluble urokinase-type plasminogen receptor (suPAR), proadrenomedullin (pro ADM), and presepsin appears promising and offers better prognostic performance than procalcitonin [ 10, 11].
These classifiers have a better prognostic performance than conventional classifiers based on clinical parameters [ 5, 6], and can predict both the response to therapy [ 7, 8], and the odds of metastasis development [ 9, 10].
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The LR combines DR and FPR, and the larger the value, the better the prognostic performance.
Thus, novel biomarkers with better diagnostic and prognostic performance are required.
Increasing clinical technical capabilities and better characterization of existing biomarkers might contribute to the introduction of multimarker combinations with better diagnostic, monitoring, and prognostic performance and to the discovery of new candidate biomarkers.
The larger value of C-statistic and AUC indicates a better discrimination ability of the prognostic performance.
Addition of RDW and RIFLE classification appears to significantly improve the prognostic performance of NEWS and better identify patients who are at moderate to high risk for adverse events.
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