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To the extent that the cost of expression is dominated by such factors as the energetic cost of amino acid polymerization and the use of the translational apparatus, as appears to be the case for E. coli (Stoebel et al. 2008), the model predicts that the rate of synthesis will be the better predictor of evolutionary rate.
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Nonetheless, closeness, and in particular betweenness, seem to be better predictors of evolutionary rates than degree (fig. 1 and table 1).
Thus, irrespective of the experimental method employed, we found that (1) ePPID is a better predictor of protein evolutionary rate than PPID, (2) ePPID is a more robust predictor of protein evolutionary rate than PPID, and (3) the contribution of ePPID to protein evolutionary rate is statistically independent of expression level.
These results indicate that ePPID is a better predictor of protein evolutionary rate than PPID.
Moreover, with the exception of the "DIP-FULL" dataset, the partial correlations between ePPID and protein evolutionary rate are more significant than those between PPID and protein evolutionary rate after controlling for protein abundance (Table 3, the last column versus column 4), further indicating that ePPID is a better predictor of protein evolutionary rate than PPID.
Analysis of hub proteins in the Structural Interaction Network further supported ePPID as a better predictor of protein evolutionary rate than the number of distinct binding interfaces and clarified the slower evolution of co-expressed multi-interface hub proteins over that of other hub proteins.
They argue against explanations that are based on selection for protein function on the grounds that the rate of synthesis of a yeast protein (as inferred from mRNA abundance) is a better predictor of its evolutionary rate than is the protein's abundance.
The observed values of τ suggest that expression levels are better predictors of the evolutionary rate than are connectivities.
We find that expression levels are better predictors of the evolutionary rate than a protein's connectivity.
Which is a better predictor of memory loss?
"That's a better predictor of the future than a head-to-toe exam".
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