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However, at larger effect sizes the Caucasian sample set was better powered (63% power at OR = 1.2, 90% power at OR = 1.3 and 99% power at OR = 1.4).
Over the next decade 3 times better battires in 10 times better powered chips.
These data are in line with larger, better powered studies of walking interventions (12).
It could be speculated that this AT effect will gain statistical significance in a better powered trial.
Although better powered than VITA-D, follow-up is still short at 24 months, in comparison with epidemiological literature in general.
The results of larger, better powered, multicenter clinical trails are necessary if we are to assess accurately the benefit of DHP-PMX.
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Generating a consistent set of genotypes in candidate genes within a large sample may in the short term provide a better balance between sample size and number of testable hypotheses than can be provided by the more expensive and extensive GWAS, and will likely permit a better-powered assessment of the contribution of epistasis to complex traits.
In contrast, better-powered studies, in which greater attention was given to quality control of typing, found no evidence for association in either direction (25, 33).
To confirm if we could replicate these findings with better-powered analyses, we performed ROI analyses based on regions showing significant group differences in these previous VBM studies.
Use of frameworks incorporating imaging and genetic analysis into one model may provide better-powered analysis in future studies [ Batmanghelich et al., 2013].
Given the lack of association in the better-powered cross-national data for these cognitive outcomes, these findings should be interpreted with caution.
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