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Discover Ludwig"better potency" is a grammatically correct phrase and can be used in written English
It refers to something having a greater strength or effectiveness. You can use it when comparing the potency of two things, such as medications, treatments, or even ideas or arguments. Example: The new and improved formula has a better potency, providing faster and more long-lasting relief for cold and flu symptoms.
Exact(46)
The latter were merged in a single compound that exhibited a 200-fold better potency than the original hit compound.
The vinyl sulfones also inhibited intracellular DPPI, and for this application the more stable inhibitors exhibit better potency.
Especially, 2i showed better potency than GBR-12909 (IC50 = 14 nM) which was used as reference compound for dopamine transporter.
From this series, compounds, b9, b10, b11 and b12 possessed better potency against NCI-H226 and NPC-TW01 cancer cells (Table 19, Fig. 5) [25].
One compound, 62, with an IC50 value of 0.6 μM, displayed better potency than the original chalcone 2 against the strand transfer process.
SAR studies at the thioether moiety indicated that substitution at this position was mandatory and better potency was achieved with small groups.
Similar(14)
For the later study, we selected to use those compounds with PI3K inhibition IC50s which had been either shown in Figure 2a and/or were in supplementary material with determined PI4KA IC50s of 1.0 μM or better potencies.
Initial efforts led to analogues with markedly different core structures possessing even better ATPase potency (e.g. 17 and 18, Figure 3); however, these potency gains did not translate to improvements in the cell-based potency.
Domed colonies of piPSCs might have better developmental potency in vitro and in vivo than the flattened ones.
The optimized compound 9b displayed better antitumor potency in vitro and in vivo than the lead compound ZYY14.
It was found that the presence of an electron-donating group on the phenyl ring led to better inhibitory potency, a trend consistent with the results from the previous papain studies.
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