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The significant benefit of utrophin modulation with daily oral treatment SMT022357 confirms first, that it is feasible to generate structurally different oral small molecule drugs capable of maintaining utrophin transcription and secondly, these second-generation compounds have demonstrated significant in vivo efficacy and better physicochemical properties compared with SMT C1100.
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AuNPs have different physicochemical properties compared to the bulk solids because of its large surface to volume ratio.
Due to their small size, the NM exhibit different physicochemical properties compared to their respective bulk material.
From the over 390,000 remaining entries, those with similar physicochemical properties compared to the FXR-active dataset were kept.
Antibacterials are known to have vastly different structural and physicochemical properties compared to nonantiinfective drugs, as illustrated herein by principal component analysis (PCA).
Indeed, antibacterials typically have different physicochemical properties compared to other drug classes, such as higher molecular weight and increased polarity, and often violate rules established for oral bioavailability.
These novel imidazolium ionic liquids to be tested in this work possess the improved physicochemical properties compared to the conventional imidazolium ionic liquids (Maton et al. 2012).
Antibacterials have vastly different structural and physicochemical properties compared to those of nonantiinfective drugs, presenting an enigma to currently available tools developed for eukaryotic systems.
This multivariate analysis indicated that antibacterials have substantially different and more varied structural and physicochemical properties compared to other drug classes.
The 3dct -s) models were not able to find compounds classically considered as drug-like according to their physicochemical properties (compare Fig. 2).
These Ce6-cur conjugates showed better physicochemical properties and higher singlet oxygen generation capability.
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