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They suggest that better peptide affinity for the protein requires a Lys at second position, retention of aromatic residue at the last position, and absence of acidic residues at any position in the transit peptides.
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Kampstra, A. S. et al. The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules.
Two assays measuring peptide affinity for TAP are available.
Mechanisms other than peptide affinities for HLA molecules may be underpinning some of these associations.
This method not only predicts T helper epitopes, but also indicates peptide affinities for HLA allotypes.
Peptide affinity reagents may serve as useful alternatives to monoclonal antibodies in AAV capsid recognition, and offer readily scalable solutions for purification of clinical grade AAV vectors.
This difference in the observed affinity between peptides, in particular for the alanine mutations, suggests that Tyr29 and Tyr68 are important in determining peptide affinity.
Palladium presented then a better affinity for FAU zeolite and copper oxide had a better affinity for zirconia.
The binding affinity of the peptide is comparably better than some known peptide inhibitor affinities for their own target proteins.
The computationally assisted peptide screening and design enabled identification of linear peptides with affinity for ZnO with limited experimentation.
Moreover, all the peptides demonstrated affinity for the tumor cells evaluated.
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