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Significant higher BDNF levels were found in GIG rats, leading to significantly better motor function recovery.
Gradually increased training intensity (GIG) induced significantly better motor function recovery.
Rats in LG and HG also exhibited significantly better motor function recovery from the 6th day than the control.
Other studies also show that higher BDNF level in the brain indicates better motor function recovery after stroke [ 7, 37].
It was observed that Sal B introduced at 5 mg/kg/day resulted in better motor function recovery.
In addition to the promotion of transplanted cell survival, significantly better motor function recovery compared to hUMSCs group was achieved in the NT-3-hUMSCs group.
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GIG rats showed the highest BDNF concentrations in the hippocampus and striatum and had the best motor function recovery.
Results indicated that rats with treadmill gradually increased intensities better regain motor function recovery.
When combined, the TR and the RFVE treatments seem to regain a better motor function compared to the recovery induced by the simple augmenting of the conventional rehabilitation program intensity.
Regarding motor function recovery, both MSC transplantation groups achieved significantly better outcomes than the control group (BBB scale 6.5 ± 1.8).
Based on their results, both axonal regeneration, which was verified via HRP retrograde tracing, and motor function recovery, which was assessed by BBB scoring, were significantly better in the combination group compared to normal OECs and the control group.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com