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The climbers had unexpectedly better mitochondrial function than the trekkers at baseline.
The first significant finding of this study was an unexpected difference in PCr recovery halftime (and hence mitochondrial function) between climbers and trekkers at baseline, with the climbers having significantly shorter halftimes (and hence better mitochondrial function) than their altitude-naïve counterparts.
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The analysis of sperm, performed after morphological selection by high-magnification microscopy, indeed showed a significantly better mitochondrial function, chromatin status, and euploidy rate than observed in unselected cells.
Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16±1 vs. 22±2 s (mean ± SE, p<0.01).
This implies that longer mitochondrial stationary sites are an indication of better mitochondrial function.
Also consistent with previous work is our finding that females have greater mitochondrial function than males.
Further functional characterization of these proteins may enable a better understanding of mitochondrial function.
In some experiments, reperfusion was continued for 24 hours and injury was assessed by mitochondrial function rather than CK release.
One thing that's needed, Meyer says, are better ways to evaluate mitochondrial function in whole organisms.
In principle, measurement of mitochondrial function in vivo is better than measurement in vitro.
In vitro, it dose-dependently inhibits mitochondrial function even in cells other than hepatocytes [ 27- 32].
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