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The climbers had unexpectedly better mitochondrial function than the trekkers at baseline.
Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16±1 vs. 22±2 s (mean ± SE, p<0.01).
The first significant finding of this study was an unexpected difference in PCr recovery halftime (and hence mitochondrial function) between climbers and trekkers at baseline, with the climbers having significantly shorter halftimes (and hence better mitochondrial function) than their altitude-naïve counterparts.
This implies that longer mitochondrial stationary sites are an indication of better mitochondrial function.
In an animal model of Alzheimer's disease, transgenic mice consuming a ketogenic diet exhibited better mitochondrial function and less oxidative stress and β-amyloid deposition when compared with normally fed controls.
The analysis of sperm, performed after morphological selection by high-magnification microscopy, indeed showed a significantly better mitochondrial function, chromatin status, and euploidy rate than observed in unselected cells.
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An analysis of Mitochondrial Membrane Potential (MMP) made with the potentiometric dye TMRM also indicated that EGFP-p53R-positive cells are less susceptible to undergo MMP decrease with respect to those positive for EGFP-p53P, suggesting that these cells have a better preserved mitochondrial function.
In this review we discuss facts and ideas available in the literature regarding the energy metabolism of mature brain in order to better understand mitochondrial functions in CNS.
Further functional characterization of these proteins may enable a better understanding of mitochondrial function.
Nevertheless, H2S did normalize the sepsis-related increase in "leak respiration" - which was less pronounced during hypothermia - thus allowing for better maintenance of mitochondrial function.
One thing that's needed, Meyer says, are better ways to evaluate mitochondrial function in whole organisms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com