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Similarly, better methods to identify off-target cleavage sites have also been developed.
The need for better methods to identify similarities in microarray data sets arises from the fact that although the analysis techniques have constantly improved over the past years, one of the biggest hurdles remains the comparability among distinct data sets produced by different researchers and laboratories, resulting in lists of genes which do not overlap, or overlap in a very limited fashion.
For this reason, we need better methods to identify growth restricted babies, especially in epidemiological studies.
Hence, we feel that both BMD measurement with DXA and vertebral fracture assessment are better methods to identify such patients.
Thus, regarding the important health consequences of osteoporotic VFs, together with the fact that most of them are undiagnosed, emphasizes the need for developing better methods to identify patients with asymptomatic VFs.
An EMA brainstorm session held with regulators and pharmaceutical industry representatives in 2007 made clear that a special need exists for dialogue about new high-risk advanced therapies and technologies and for new scientific approaches in targeted drug development, such as validation of biomarkers, choice of study endpoints, or better methods to identify treatment responders.
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Ongoing genome-wide experimental screens for enhancers [29], or functional genomic projects such as MOD-ENCODE, may ultimately provide the necessary functional data to enable – or render superfluous - better comparative methods to identify D. melanogaster regulatory sequences.
According to the results, the GTI was better able than most of the previous methods to identify known oncogenic outlier genes.
There are a large number of methods to identify covarying positions [12] in part because some methods work better on certain alignments than on others.
A better strategy would be to combine different classifiers, from more specific to more sensitive methods, to identify a broader spectrum of 7TMR protein candidates.
With no accepted methods to identify adulteration, the character and scale of problems were still debated.
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