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These results demonstrate that P14 effector T cells generated in the presence of IL-2 from 0 h on attained better effector function and were highly effective in reducing tumor burden in vivo.
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CD8-enhanced pMHCI ligands were recognised at lower concentration and induced substantially better effector function for a given quantity of antigen (Fig. 5, 6).
This suggests that the polyfunctional T cells induced by the DNA/rAd5 prime/boost exhibit better effector function than cells primed by DNA alone.
The fact that tumor specific T cells transduced with wtAkt displayed better effector functions than T cells transduced with myr-Akt actually makes this strategy more convenient for clinical translation.
We anticipate that IgPred will be beneficial in designing a better vaccine and immunotherapy, with most appropriate effector function, and several other clinical applications.
Further investigation on the correlation between trastuzumab-mediated immune effector function and HER2 downregulation in patients treated with trastuzumab should help us to better understand the role of immune modulation in the anticancer efficacy of trastuzumab.
Ohnmacht, C. & Voehringer, D. Basophil effector function and homeostasis during helminth infection.
The sum of minimum signals necessary for immune cell activation; specifically for T cell activation, effector function and proliferation.
Regulation of cell metabolism is essential to support the demands of lymphocyte growth and effector function and may regulate tolerance.
Rao, R.R., Li, Q., Gubbels Bupp, M.R. & Shrikant, P.A. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8+ T cell differentiation.
Irvine, K.M. et al. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.
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