To better define the values of the groups, heat capacity data at 298 K for 126 organic substances were used with the 469 heat capacity data for 32 ionic liquids.
Future investigations could better define the therapeutic value and required duration of RR training to counter stress-related disorders.
In order to better define the prognostic value of Ki-67/MIB-1, we performed a meta-analysis of studies that evaluated the impact of Ki-67/MIB-1 on disease-free survival (DFS) and/or on overall survival (OS) in early BC.
Moreover, as the biological function of WT1 has been shown to be influenced by other interactive proteins like p53 and par-4, the expression status of thesegenes should be evaluated in order to better define the prognostic value of WT1 gene expression [ 27, 28].
In order to better define the possible prognostic value of MMP14 expression in MM, we decided to investigate MMP14 expression by immunohistochemistry in a group of well-characterized MM specimens.
There is a need to better define the upper normal limit value of liver stiffness measurements, as well as the choice of a consensual cutoff for advanced fibrosis, because of the risk of false negatives.
Therefore, it is important to better define the ranges of laboratory values found in healthy adults likely to enroll in future trials [2], [3].
Future studies need to evaluate the clinical utility and cost effectiveness of preoperative ROTEM and better define the association between ROTEM values and specific hypercoagulable conditions.
Finally, the possibility to perform genomic studies on a large number of samples would also improve the knowledge on the biological background of many kinds of tumor, including GIST, allowing to better define the real prognostic and predictive value of several biological markers, not yet transferred into clinical practice because of their role still uncertain.
