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In order to better define the functional role of PLN in skeletal muscle we assessed SERCA function in these mice, focusing our analyses on the postural muscles – soleus and gluteus minimus – since these muscles normally contain approximately 55-65% and 27% type I fibers, respectively.
Specifically, the strength and the novelty of our findings comes chiefly from the natural versus constrained contrast enabling us to better define the functional properties of key areas involved in the control of grasping.
The quantitative measurement, currently in progress, will further expand the utility of our methods to better define the functional consequences of PSSG.
Finn and colleagues created a liver-specific b5 conditional knockout mouse in order to better define the functional importance of the CYP b5 interaction.
The presence of GPCRs and GPCR signaling proteins in diatoms suggests a secondary signaling mechanism that warrants further experimental investigation to better define the functional roles of these proteins in diatoms.
Several groups have exploited these attributes to study various pathogenic mtDNA mutations – for example, in the genes encoding subunits of complexes III (cytochrome b) and IV (COXI, COXIII) (Meunier, 2001; Meunier et al., 2013), and in mt-tRNA genes (Feuermann et al., 2003; Montanari et al., 2008), which have helped to better define the functional consequences of these mutations.
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Recent studies also suggest that DOCK5 cooperates with DOCK1 for the differentiation of myofibers [ 154], and clearly, crossing these mice with Crk II or CrkL mice should better define the level of functional interactions.
This type of approach should help to better define the clinical application of these functional hemodynamic parameters.
Using both parent and child perspectives in defining the latent variables increases the likelihood of measuring the intended construct, while placing these constructs within a single model helped better define the complex relationships that contribute to functional disability in children with FGIDs.
Clearly, additional functional analyses are warranted to better define the mechanistic basis to these observations.
BCVA was included in the model in order to provide a functional outcome that could help better define the latent class "retinal thickness change".
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better define the later
better represent the functional
better define the analytical
better define the mechanistic
better define the therapeutic
better define the various
better define the scientific
better interpret the functional
better assess the functional
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better clarify the functional
better define the exact
better define the transcriptional
better define the non-responding
better evaluate the functional
better define the potential
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com