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In this paper, we used a combination of genetic and cell biological studies in C. elegans to better define the function of the sorting nexin LST-4 in apoptotic cell corpse clearance.
To better define the function of CDC-42 in engulfment signaling, we generated double mutants between cdc-42 and different canonical engulfment mutants.
The use of fluorescent protein biosensors in combination with fast high resolution life cell microscopy could help to better define the function of Rac/Cdc42-carrying endosomes.
Pharmacological inhibition seems to protect humans and mice from sarcopenia (Carter and Groban, 2008), but further studies are needed to better define the function of ACE during sarcopenia.
Therefore, it is important to better define the function of histone modifications and the interplay among the enzymatic activities (COMPASS-like, hBRE1, PAF1 complex, USP22, and so on) that promote these modifications if we are to fully understand how chromatin contributes to both normal and aberrant activated transcription in mammalian systems.
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In the present study we sought to better define the role of AEA in modulating immune functions of primary human T cells, with a special focus on the key regulators of autoimmune inflammation: Th17 lymphocytes [17].
In an effort to better define the cellular function of LRRK2, we conducted yeast two-hybrid screens to identify potential LRRK2 interacting proteins.
Further studies are needed to better define the physiological function of cathepsin activity at these stages and how these activities are intertwined in the maturation program of chondrocytes and other cell types.
To better define the transcriptional control functions of PPARγ and its heterodimerization partner, RXR, during adipogenesis, we employed the paired-end ditag (PET) technology to characterize chromatin immunoprecipitated (ChIP -enriched DNA fragments and mapped, in an unbiased manner, the binding sites of these nuChIP -enrichedreceptors (NHR) on a genome-wiDNAscale.
While additional studies will be required to better define the cell biological functions of MIP and PI 3,5 P2, we propose that the MIP-PI 3,5 P2 MIP-PI 3,5 P2hway isignalingrtant contributor for aging sarcopathwayand as such could be explored as a new therapeutis option for the treanment of not only muscle myopathimportantalso for aging sarcontributor
Longitudinal studies are required to better define the complex relationship between REE, falling renal function, oxidative stress and inflammation in patients with CKD.
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better define the applicability
better define the basis
better devolve the function
better define the stress
better define the dysfunction
better define the subpopulation
better define the treatment
better define the modulation
better define the spectrum
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better define the content
better define the usefulness
better define the country
better define the sequence
better characterize the function
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