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To better define the efficacy of these techniques, a systematic review of different ventilation strategies during and after CPB was performed.
Several studies are still ongoing to better define the efficacy of these agents in the treatment of leukemias, as well as to determine the best schedules, the role of combination with other agents, and the role of these agents in different settings, such as the management of minimal residual disease.
However, further targeted studies are needed to better define the efficacy as well as safety profile in frail and older patients with comorbid diseases.
They should yield informative host metabolic and immune as well as microbial biomarkers of healthy growth that can be used to study the pathogenesis of undernutrition, better classify malnourished states, and better define the efficacy of various treatment regimens.
Future studies with long-term follow-up, larger patient groups, and a standardized method for preparation of the injection are needed to better define the efficacy of these treatments for lateral epicondylitis.
Phase 3 studies of canagliflozin are now under way to better define the efficacy profile across multiple uses, including in monotherapy and various combinations, and to better understand the longer-term safety and efficacy profile of this agent.
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Further investigation is necessary to better define the indications, efficacy, role, and long-term oncologic outcomes of focused ultrasound treatment.Level IV, therapeutic study.
Because type 2 diabetes is a chronic disorder, study durations beyond 52 weeks may better define the long-term efficacy and safety of canagliflozin.
Future clinical trials are needed to better define the safety and efficacy profiles, especially in sicker patients and for more serious infections, where the need to improve management and reduce costs is great.
However, in order to better define the profile of efficacy and safety of beta-blockers in older patients, further data are needed from targeted clinical trials and rigorous observational studies, showing definite improvement in outcomes as well as clearly favorable benefit-risk analysis in typical older heart failure patients irrespective of comorbidity, frailty and polypharmacy.
PROs as symptoms, functional status, treatment adherence, satisfaction with care represent useful data to corroborate the clinical data (efficacy and safety), helping clinicians to better define the drug profile.
More suggestions(16)
better define the cost effectiveness
better determine the efficacy
better define the therapeutic
better define the value
better reflect the efficacy
better assess the efficacy
better define the applicability
better define the stress
better clarify the efficacy
better define the subpopulation
better understand the efficacy
better define the modulation
better define the spectrum
better define the content
better define the country
better define the sequence
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com