We believe that this feature is most probably due to the better bioavailability and higher stability of HA-Acet with respect to the free HA form.
We saw better bioavailability and tumor targeting efficiency with minimum secondary organ drug distribution.
The DPA714 radioligand has a longer half-life, a better bioavailability, and less nonspecific binding than PK11195 [ 140].
Artemisinin, a potential antileishmanial compound with poor bioavailability and stability has limited efficacy in visceral leishmaniasis.
But low aqueous solubility, poor bioavailability, and stability limit its efficacy against prostate cancer.
CDs can be used to enhance solubility, bioavailability and stability of pharmaceuticals [41 43].
Macrocyclic peptides show high target affinity, bioavailability, and stability and thus have enjoyed considerable use as therapeutics.
Yet, the therapeutic applicability of native peptides in humans may be limited due to issues with (oral) bioavailability and stability.
To increase bioavailability and stability of EGCG, particular studies have elucidated structure-modified compounds with higher efficacy, which also possess anticancer activities [ 39, 43].
Excipients are essential components of medicinal products required for manufacturing processes to assure several properties such as solubility, bioavailability and stability of the final dosage form.
