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The perfect palindrome, may be expected to be a better binding site for CymR.
Furthermore, the changes would make the DR4 a better binding site for the TR and is identical to the MPO DR4 that responds to TR [ 26].
However, when the rotaxane was protonated, the ammonium group was a better binding site for the macrocycle than the triazolium ring, and so the macrocycle blocked the catalytic center, preventing the reaction.
When the secondary amine of the rotaxane was not protonated, the triazolium ring provided a better binding site for the macrocycle and the dibenzylamine group was exposed, and could therefore participate in catalysis.
Furthermore, the fourth direct repeat acquired a G to A change in the sixth nucleotide of the direct repeat and would be predicted to make the second DR2 a better binding site for RAR as it is identical to the site in the MPO gene that responds to RA [ 26].
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Interestingly, in NWMs these elements are well conserved in the CAMP promoter Alu and have acquired additional changes that make them potentially better binding sites for RAR and TR.
Other primate malaria parasites, such as P. hylobati, P. inui, P. cynomolgi, P. simium, P. fieldi, and P. simiovale, showed better binding sites for pmk 8 than P. vivax S- or A-strains.
The binding site for pore blockers is indicated.
Our study revealed a nucleosomal DNA binding site for hORC1BAH.
The heparin binding domain 3 (HBD-3), also located at the C-terminal end, is the major binding site for most studied bacterial Vn-binding proteins8.
While the aldehyde-binding sites of ALDHs are as diverse as their substrates, the binding site for NAD+ of ALDHs has been known to be relatively conserved46.
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