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In general, clinically relevant and significant late toxicities such as hematuria, which occur infrequently, may be better assessed in a late toxicity scale (RTOG, LENT-SOMA) as opposed to a HRQoL instrument.
Though detailed sensitivity analyses were undertaken, given heterogeneity in the study protocols, clinically relevant differences could have been missed and might be better assessed in a meta-analysis of individual patient data.
Assessment of severe hypoglycaemic episodes (ADA category 1) was excluded from the study because the clinical symptoms and the consequences of severe events (seizure, coma, and even death) are qualitatively different from less severe events and would be better assessed in a separate study.
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Improvements in IBD care would probably be better assessed in an ambulatory setting.
Given the low mRNA expression level and the role of transcription factor in gene expression, NRF2 function would be better assessed in future studies using an activity assay to more definitively show that NRF2 function is directly regulated by miR-144.
While risk scores could be computed, and can be further refined to a general patient profile, also the medication classes could be better assessed in T2D context.
Some information concerning pharmacokinetic properties may be obtained but are better assessed in other types of trials.
The rationale for this approach is that submerged segments can be better assessed in 2D.
Action on the combined barrier formed by the glycocalyx and the endothelial cell bodies is better assessed in the presence of colloidal substances [ 6].
Moreover, our results also suggest that Pb, Cd and Hg concentrations in the reproductive tract are not reflected by blood levels and those metals would be better assessed in seminal plasma [ 6, 15, 29].
Items on the frequency and severity of diarrhea were removed from the Diary, as the potential accuracy and reliability of bowel movement frequency and stool consistency would be better assessed in the Event Log.
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