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Our primary aim is to evaluate the clinical safety and technical feasibility of this procedure, and secondarily to measure the influence, if any, on clinical and beta-amyloid imaging markers of AD.
Immunohistochemistry was carried out for the ionized calcium binding adaptor molecule 1 (Iba1), a marker for activated microglia to measure the inflammation response [ 49], beta-amyloid plaques, congophilic plaques and doublecortin (DCX), a marker for immature neurons.
Most experts believe accumulations of a protein called beta-amyloid in the brain are, at least, a marker for Alzheimer's and perhaps a cause (see illustration).
Beta-amyloid plaques.
Beta-amyloid is thought to lay the groundwork for dementia.
The beta-amyloid findings may have implications beyond Alzheimer's.
Plasma beta-amyloid linked to cognitive decline.
Normal people with beta-amyloid deposition showed more not less activity than people without beta-amyloid.
Jack, C.R. Jr. et al. Brain beta-amyloid load approaches a plateau.
One trial being conducted right now involves slowing down the production of the beta-amyloid.
It reduces the frequency with which the precursor protein is cut into the elongated beta-amyloid.
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