Exact(5)
Arita, M. Mechanism of Poliovirus Resistance to Host Phosphatidylinositol-4 Kinase III beta Inhibitor.
We showed that the combined S1P and LPA treatment of undifferentiated hiPSCs resulted in increased nuclear accumulation of β-catenin, the canonical Wnt signaling pathway mediator, and synergized with CHIR99021, a glycogen synthase kinase 3 beta inhibitor, to enhance mesodermal induction and subsequent cardiac differentiation.
In the present study, the gene encoding nuclear factor kappa beta inhibitor α (NFKBIA), was upregulated.
In addition, ruboxistaurin, a PKC beta inhibitor, also suppressed the proliferation.
Among disease-modifying agents, the antioxidant α-lipoic acid met secondary endpoints in a recent clinical trial in peripheral diabetic neuropathy [ 3] and the protein kinase C beta inhibitor (ruboxistaurin) was effective in a subgroup of patients with less-severe symptomatic diabetic neuropathy [ 4] whereas aldose reductase inhibitors were found to be ineffective [ 5].
Similar(55)
Lamarche, M. J. et al. Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.
Spender, L. C. et al. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
In breast cell lines, PTEN loss was shown to sensitise to p110 beta inhibitors, a ubiquitously expressed class IA PI3K isoform [ 61].
By the mid-2000s, theardeard of a new drug — an interleukin-1-beta inhibitor — that was used to treat exceedingly rare inflammatory diseases.
Enzastaurin (LY317615.HCl) is an oral selective PKC-beta inhibitor with antiproliferative efficacy in various tumor models.
Calphostin was added as a protein kinase C inhibitor, and ET-OCH3 was added as a phospholipase C-beta inhibitor.
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