Sentence examples for beta cells that are from inspiring English sources
The latter concern may be addressed by recently described glucose-responsive mature beta cells that are derived from human embryonic stem cells (referred to as SC-β cells), which may represent an unlimited source of human cells for pancreas replacement therapy4.
"Regular beta cells that aren't protected with the mutation are gone within days, and beta cells with the mutation kick around for weeks," Kissler said.
Beta cells that are chronically stimulated by glucose ≥10 mM become basally hyper-activated, with left-shift of the concentration-response curves for glucose-stimulated insulin synthesis, secretion and metabolic activation [6], [22], [23].
It was not known whether de-differentiated beta cells in diabetic patients can recover to form mature beta cells that are capable of producing insulin.
Physiological glucose control could be achieved by genetically engineering surrogate beta cells that are capable of synthesising, storing and secreting insulin in response to metabolic signals.
There are a few studies identifying proteins in beta cells that are enriched presynaptically in neurons and form a presynaptic stimulus secretion complex.
We discovered a population of immature beta cells that is present throughout life and forms from non-beta precursors at a specialized micro-environment or "neogenic niche" at the islet periphery.
Glucose responsive mature beta cells that were derived from human embryonic stem cells were encapsulated in an alginate derivative and transplanted into STZ-induced diabetic rats.
Gene expression of these beta cells in the pancreas could then be compared with human beta cells that were transplanted into mice.
However, after immature precursor cells were transplanted into immunodeficient mice, maturation progressed to produce beta cells that were convincingly normal with regard to multiple characteristics.
In this study, we identified the Groucho protein AES (Amino-terminal Enhancer of Split) as a HNF1α-specific physical binding partner and functional repressor of HNF1α-mediated transcription, which has a direct link to glucose-stimulated insulin secretion in beta-cells that is impaired in the HNF1α mutation-driven diabetes.
