Sentence examples for beta cells compared to from inspiring English sources
It also improved serum insulin levels, β cell function, reduced insulin resistance and restored pancreatic beta cells compared to the diabetic group.
This binary classification approach may provide an overestimate of the remaining beta cell mass, as insulin-positive islets may exhibit a reduced complement of beta cells compared to age-matched controls.
We identified 2000 and 1400 transcripts that are enriched/depleted in beta cells compared to alpha cells and INS-1 cells, respectively.
The Insulin 2 (Ins2) and Ins1 genes are the second- and third most significantly enriched genes in beta cells compared to alpha cells, after the beta cell-specific transcription factor Mafa, which serves as a potent confirmation of the high purity of the beta cell population obtained by the use of our mIns1-H2b-mCherry reporter mouse.
There was a modest increase in integrin beta 1 (CD61) in CD44+/CD24- cells compared to CD44-/CD24+ CD44-/CD24+
The principal islet in the treated fish still showed very weak insulin expression but a few new beta cells (about 5%% of the islet cells, compared to 40 70 % in control fish) can be detected in the principal islet as well as throughout the exocrine tissue as isolated cells or as small clusters of Ins-expressing cells next to CACs and ductal cells marked by GFP (Fig. 9c, yellow arrows).
Proteins of lipid biosynthesis, especially involved in beta oxidation were also lowered in fast growing cells compared to RP.
Interestingly, differentiation into functional beta-cells is greatly improved when starting with EP cells compared to undifferentiated hPSCs.
In obese individuals, this relationship is curvilinear, with an inflection of blood glucose with a deficit of ∼50% or more beta cells compared with controls.
Human islet grafts from dysfunctional donors were made up of only 10 20% beta cells compared with 75% in normal human islets.
However, approximately 6% of genes show species enrichment, including 61 ligands or receptors (ESM Table 4), including the enrichment of Prlr, Ghr and Cntfr in mouse beta cells compared with human beta cells [ 41, 48].
