Sentence examples for beta cells can be from inspiring English sources

No differences were seen in the viability of the beta cell or alpha cell-enriched preparations isolated from TO1317- or vehicle-treated rats and cultured in the control condition In prior work we have shown that primary beta cells can be less susceptible or even resistant to palmitate toxicity, and that this property is heterogeneously expressed [7].

Thus, insulin release by human beta cells can be increased by about four- to fivefold and beta cell mass enhanced by about 50% during insulin resistance [ 64, 65].

Taken together, the above observations emphasise that further work will be required before mature beta cells can be readily generated from hESCs.

An exciting study has demonstrated that beta cells can be derived not only from stem cells but also from glucagon-expressing alpha cells of the islets (Zhou et al, 2008).

Lineage tracing studies have demonstrated that these ' de novo beta cells' can be derived from pre-existing beta cells (Dor et al, 2004), or by conversion of alpha cells, after almost 90% beta-cell ablation (Thorel et al, 2010).

The presented data indicate that liver cells and other non-beta cells can be engineered to produce and secrete insulin.

In conclusion, our studies of beta-cell regeneration in the STZ-diabetic mouse may have implications for patients with type 1 diabetes and suggest that if the ongoing immunological destruction of beta-cells can be prevented, proliferation of the remaining beta-cells in the presence of insulin (and possibly other agents) may lead to a restoration of normal glucose tolerance.

In vitro, Hayek and coworkers reported that human beta-cells can be stimulated to enter the cell cycle in vitro when cultured on a complex extracellular matrix [ 9], but this has been disputed as possibly being due to replication of exocrine cells contaminating the islet preparations [ 10].

Other groups found that chloride channels in respiratory epithelial cells can be activated by beta agonists via an increase in intracellular cAMP [ 5].

Human embryonic stem cells can be directed to become fully developed beta cells and there is expectation that induced pluripotent stem (iPS) cells can be similarly directed.

PDX1-positive/insulin-negative cells can be considered as cells committed toward a beta cell-like phenotype without having achieved terminal differentiation yet.