Sentence examples for beta cells and that from inspiring English sources

"The biggest hurdle has been to get to glucose-sensing, insulin-secreting beta cells, and that's what our group has done.

"The biggest hurdle has been to get to glucose-sensing, insulin-secreting beta cells, and that's what our group has done," said Professor Melton, who was inspired to start the research 23 years ago after his infant son Sam was diagnosed with type-1 diabetes.

We herein report that cytokines promote TF expression in islets and beta cells and that TF/FVIIa signalling impairs islet function and augments beta cell death in response to cytokines.

These results suggest that sGRP78 functions as a pro-apoptotic receptor in beta cells and that the underlying mechanism is mediated, at least in part, by ER stress.

It has been shown that there is a reserve capacity of beta cells and that type 1 diabetes only becomes clinically apparent when the beta cell mass drops under a critical threshold (< 30%) [ 6, 10].

Moreover, the mapping of T1DBase expression dataset and QTL information onto T1D HIDN confirmed respectively that 100% of the highlighted candidates are expressed in beta cells and that 50% (18/38) of them are localized within genetically identified T1D susceptibility regions either in human, rat and mouse [ 25- 27] (Additional file 9).

We asked which ones are present in the beta cell, and that gave us 1,100 transcription factors to choose from.

In particular, observations that beta-cell regeneration derives primarily from existing beta-cells and that insulin secreting beta-cells remain functional in patients with established type 1 diabetes, raise the possibility that beta-cell regeneration may contribute to the recovery in patients with autoimmune diabetes [20], [21], [22], [23].

This is consistent with the presence of a small number of still functional beta cells and implies that beta cells are either escaping immune attack or undergoing regeneration.

In contrast, islets of vehicle-treated db/ db mice exhibited an abnormal architecture, with reduced beta cells and increased alpha cells that were scattered throughout the islet core (Fig.  5a).

Though Melton sees betatrophin primarily as a treatment for type 2 diabetes, he believes it might play a role in the treatment of type 1 diabetes as well, perhaps boosting the number of beta cells and slowing the progression of that autoimmune disease when it's first diagnosed.