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Beta cell function was increased (%B mean 225%, SD 88%, range 87%–348%), while insulin sensitivity was decreased (%S mean 46%, SD 52%, range 14% 198%) resulting in an increased insulin resistance (HOMA IR mean 3.7, SD 2.1, range 0.5 to 7.0).
Pancreatic beta cell function was assessed using the OGTT data.
This suggests that beta cell function was only temporarily disrupted.
Beta cell function was assessed by AIR in 298 full-heritage Pima Indians with NGT.
Modelling analysis of beta cell function was performed during standard meal tests.
Pancreatic beta cell function was assessed by the HOMA for beta cell function (HOMA-B) [ 28].
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It is highly striking to observe that most of these TF and regulatory genes, which are likely to be functionally relevant for Ras-MAPK signaling and/or beta cell function, are overexpressed (Additional file 1: Table S1).
Basal insulin sensitivity and beta cell function were calculated from fasting plasma glucose and insulin using HOMA [15].
We know that beta cell function is adversely affected by glucose toxicity even with these mild glucose elevations [6].
Since beta cell function is affected by the concentration of glucose at the start of the test, the study protocol requested that no mixed meal test should be performed if fasting blood glucose was outside 4 11 mmol/l.
Partial preservation of residual beta cell function is considered as clinically relevant goal also in the absence of lower insulin requirements, because of a lower risk of complications [20], [21].
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