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After initial runs were conducted with variable values of deltaA, deltaM and deltaF in order to improve the acceptance levels, the best values were set to deltaA = 1, deltaM = 0.2 and deltaF = 1.
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(Missing values were set to 0).
The segmentation values were set at 0.7/1/250.
After iteration, we obtained the best physiological fit when the f NCX value was set to 2. To adjust the Ca2+ recirculation fraction to a physiological level (see Table 2), we reduced the scaling factor for the total current k NCX to 125 pA/pF.
The final threshold value was set as the one with the best performance in ten runs.
Lastly, the cutoff value was set at the median score as usual for HSF1, although the P-value is not the best at this score.
The p value was set at p<0.05.
The e-value was set to 1e-30.
The best values are marked in bold.
The best values are in boldface.
Based on the best calculated cutoff values, cutoff points at baseline were set at 18 ng/mL for TAT and 270 ng/mL for PAI-1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com