Sentence examples for best understood function of from inspiring English sources

Analyzing contractile force, the most important and best understood function of cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM).

The best understood function of Cajal bodies is the biogenesis of small nuclear and nucleolar RNPs (snRNPs, snoRNPs) involved in pre-mRNA splicing and pre-rRNA processing, respectively [25], [26].

The best understood function of piRNAs is regulating MEs in several species [ 3].

Consistently, the best understood function of piRNAs is their role in defense against transposable elements in the germline.

The control of cytoplasmic mRNA turnover by Ccr4-Not is the best understood function of the complex.

The best understood function of TSC1 and TSC2 is to inhibit the activity of mTORC1 (12– 15).

Although active IKK recognizes and phosphorylates a number of diverse cellular substrates, including FOXO3a, p65/RelA, SNAP-23, and TSC1, its best understood function is phosphorylation of the transcription factor NF-κB inhibitor protein IκBα on two N-terminal serine residues, S32 and S36.

The possibly best understood function comes from the unexpected discovery that Ogt is the enzyme responsible for the proteolytic maturation of Hcf1 in mammalian cells (Capotosti et al. 2011).

Arguably, the best-studied and understood function of mTORC1 is its role in translation control.

The best understood molecular function of the PCNA protein is its role in the regulation of eukaryotic DNA polymerase delta processivity, which ensures the fidelity of DNA synthesis and repair [44].

Despite recent findings of NF-κB-independent functions for IKK [ 5– 8], the best understood role for these kinases is phosphorylation of IκB proteins and consequentially NF-κB activation [ 1].