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The best understood example of epigenetic modification is DNA methylation, which is well-associated with transcriptional repression [ 1].
Perhaps, the best understood example of penetrance depending upon the level of expression of the wild-type allele is retinitis pigmentosa type 11 (Utz et al. 2013).
Perhaps the best understood example of molecular events involved in eIF4E regulation in an mRNP complex was described for oocyte maturation in Xenopus.
The best understood example of cytoplasmic inheritance occurs in Drosophila melanogaster, where germ plasm is maternally synthesised, localised to the posterior of the oocyte during oogenesis, and subsequently incorporated into PGCs (pole cells) during cellularisation.
Regulation of mating type in S. cerevisiae was the first and arguably remains the best understood example of cell fate regulation (e.g., Johnson and Herskowitz 1985), and the logic used for mating-type control extends to a variety of somatic cell fates (e.g., muscle, neurogenein neuron, pancreatic β-cell).
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While these examples are perhaps the best understood examples of gene-culture co-evolution, researchers have identified scores of others.
These infections often involve Pseudomonas aeruginosa and Staphylococcus aureus, two of the best understood examples of bacteria that employ quorum sensing systems as part of their pathogenesis.
The first cell divisions of early embryogenesis in C. elegans are among the best understood examples of asymmetric cell divisions.
One of the best understood examples of magnetite biomineralization is in magnetotactic bacteria, which carry out magnetite biomineralization in magnetosomes.
One of the best understood examples of a glycan-initiated signaling pathway results from stimulation of mincle, which is a simple type II transmembrane receptor expressed on macrophages (Matsumoto et al. 1999).
"This is just the best understood example,'' Blaser told me.
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