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In the R6/2 mouse, best studied model of HD, similar features have been observed [31].
The HCT116 cell line, which represents one of the best studied model of colorectal cancer cells, display constitutive activation of the two MEK isoforms (Fig. 6A).
Recognition of lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, is the best studied model of innate immunity [ 9].
164– 166 Most of the work testing the role of tubulin acetylation in ALS has been conducted in SOD1G93A mice that represent the best studied model of familial ALS.
In the next section, we will discuss the role of MPO halide system products, namely TauCl in the pathogenesis of rheumatoid arthritis, the best studied model of inflammatory disease in our laboratories.
In the best studied model of DS, the Ts65Dn mouse (Reeves et al., 1995), the growth of the neocortical wall is delayed due to the impaired production of neurons early in neurogenesis that is concomitant with a lengthening of the cell cycle in the ventricular germinal layer (Chakrabarti et al., 2007).
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Ocular dominance plasticity induced by monocular eyelid suture is one of the best studied models of experience-dependent cortical plasticity [1].
The sympathetic neuron model is one of the best studied models of neuronal apoptosis.
Developing sympathetic neurons of the superior cervical ganglion are one of the best studied models of neuronal apoptosis.
One of the best studied models of chondrogenesis is the developing limb bud [4,5], where chondrocyte differentiation is initiated by the migration and subsequent condensation of mesenchymal cells to form tightly packed aggregates [4].
Dipteran sex determination probably provides the best studied model for understanding the evolution of sex determining mechanisms.
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