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Over last few years, the best studied human and other mammalian miRNAs have revealed rules to discover and define this group of small RNAs of ∼22 nts.
The mature, enucleated erythrocyte is the best studied human cell for metabolism due to its relative simplicity and availability.
This is part of the reason why, cervical cancers derived from patients infected with those viral types, have been intensively studied, and one of the best studied human cell line, HeLa, is positive for HPV18 [ 9].
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Because of the efficiency of genotyping methods and the central role they play in the genome-wide association studies, SNPs are currently the best catalogued and studied human genetic variations.
This miRNA has been best studied in humans, where its dysregulation is implicated in breast, lung, colorectal and head and neck cancers [ 37- 40].
The functions of Poly(ADP-ribose) polymerase enzymes (PARPs) in general are best studied based on human PARP-1 (HsPARP-1).
The p53 protein is the best studied target in human cancer.
GlcNAc signaling has been best studied in the human fungal pathogen C. albicans, as the more commonly studied model yeasts Saccharomyces cerevisiae and Schizzosaccharomyces pombe lack the genes required to catabolize GlcNAc and do not appear to respond to this sugar.
Protein-coding genes are the best studied sequences of the human genome; even though coding exons only account for 1.5% of the genome.
The RA synovium represents one of the best studied cytokine networks of human autoimmune diseases [ 1, 2].
DNA methylation of cytosines at CpG dinucleotides was proposed as a mechanism of mammalian gene regulation in 1975 [ 3, 4], and as it is the best studied epigenetic mechanism in human populations we will concentrate on it in this review.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com