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Of the seven cell lines, OVCAR-3 contained a focal, high-level amplification that best recapitulated data from primary ovarian tumors (Figure 1C).
Consistent with the fluorescence-activated cell sorting data, CD44+/CD24-/ESA+ CD44+/CD24-/ESA+ormenrichedogeneous mixed cellsies that best recapitulated the morphological phenotype oformedparental cell line.
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All thing considered, the model that best recapitulates the phenotype of PGK Cre Dbx1DTA mutants is probably the CNCC ablation paradigm in chick [10], [12], [13].
Two of these groupings, medium (gain 780) and low (gain 1080), best recapitulate the nuclear localization of endogenous MSH6 without aggregation of the GFP protein.
The low and medium thresholds best recapitulate the compartment-specific localization of endogenous MSH6, while the high threshold contained cells with large aggregates of GFP, which created intensely saturated bright spots.
We distinguished 12 clusters (k) that best recapitulate the diversity of expression profiles across conditions.
The requisite NH of the internal nitrogen of the latter series presumably best recapitulates the H-bond donor property of the vinblastine C20′ alcohol.
Cross-study comparisons such as the results presented here provide targets for further research of cardiac disease that might generally apply to maladaptive cardiac stresses and are also a means of identifying which animal models best recapitulate human disease at the transcriptional level.
The LD-Spline algorithm using a D' threshold of 1 was found to best recapitulate true haplotype block boundaries and best match established algorithm block calls.
The frequencies of the seven clusters found to best recapitulate the expression profiles were examined among differentially expressed genes in all conditions.
Regardless of which hypothesis is correct, models that induce a hypoxic response in the placenta seem to best recapitulate multiple aspects of preeclampsia, and could be useful to test potential treatments for the disorder.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com