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The authors found V40≥80% to be the best predictive parameter [ 30].
Two retrospective trials investigating this found urinary output the best predictive parameter for cessation of RRT.
The rapid shallow breathing index (RSBI) is relatively the best predictive parameter for the initial assessment of readiness for discontinuation of MV support.
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But for vancomycin, in contrast to the beta-lactams, we expected this; as we have seen, AUC24h/MIC is the PK/PD parameter best predictive of clinical efficacy and is dependent only on TDD and renal function.
Then, stepwise linear regression analysis was performed to identify the best predictive model using important parameters.
In another study, the same group investigated several shape parameters for the time-intensity curve (TIC) in order to identify the best combination of predictive parameters to distinguish responders and non-responder patients.
IPCL was the best PK parameter for predicting renal toxicity, showing the best predictive values.
This combination of parameters, which showed the best predictive accuracy, is illustrated as a fuzzy rule in Figure 2A.
ROC curves for ROTEM® parameters showed that the best predictive value for MT was provided by FIBTEM MCF (area under the curve (AUC) 0.84), with a similar outcome for FIBTEM A10 (AUC 0.83) (Table 4).
Through this fivefold CV, the combination of two input parameters that provided the best predictive accuracy as an average throughout the CV was selected by means of the forward-selection method.
The total number of peaks yielded the best predictive model and is used for optimization of parameters setting.
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