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This response rate has been shown to be the best predictive marker for prognosis (Bielack et al, 2002).
Microalbuminuria remains the best predictive marker for the development of overt diabetic nephropathy and represents an independent risk factor for cardiovascular disease (CVD) (1).
In the present study we measured urinary L-FABP, NGAL, diuresis and UCr to find the best predictive marker for early allograft function in deceased donor kidney transplantation.
This finding is in line with a previous study showing that the serum RANKL/OPG ratio is the best predictive marker for annual progression of radiological damage [ 14] independent of therapy.
Although the percentage of COHb in blood represents the best predictive marker for extrapolating the total amount of CO, COHb levels do not always correlate with the degree of injury and outcome [ 5].
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In accordance to this, in a prospective study where clinical examination, TVS, serum markers, and color Doppler, were evaluated in the preoperative investigation of ovarian tumors, the size of the lesion and the TVS morphologic features were the best predictive markers for malignancy in the premenopausal women, and the morphology and CA-125 for the postmenopausal women [ 22].
The best predictive marker of response in terms of pCR was baseline Ki-67.
Retrospective studies have shown that HER2/neu gene amplification, measured using FISH, is the best predictive marker of response to trastuzumab-based therapy [ 14].
Since ESR1 is also the best-known predictive marker for adjuvant therapy with tamoxifen (Kanavos, 2006; Loi et al, 2007), we assessed clinical relevance of NR2E3 expression in patients with ER-positive breast cancer who received systemic tamoxifen treatment (subset of IJB cohort, n = 263).
To the best of our knowledge, there has been no previous report explicitly using cLNR as a predictive marker for PMRT, especially focusing on patients with pN1 disease.
"Cognitive tests show no signs of dementia in these participants now, but we'll be interested to see if a lower clearance rate is a predictive marker for future diagnosis of Alzheimer's disease," said Bateman.
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