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The best predictive marker of response in terms of pCR was baseline Ki-67.
This response rate has been shown to be the best predictive marker for prognosis (Bielack et al, 2002).
Microalbuminuria remains the best predictive marker for the development of overt diabetic nephropathy and represents an independent risk factor for cardiovascular disease (CVD) (1).
Retrospective studies have shown that HER2/neu gene amplification, measured using FISH, is the best predictive marker of response to trastuzumab-based therapy [ 14].
In the present study we measured urinary L-FABP, NGAL, diuresis and UCr to find the best predictive marker for early allograft function in deceased donor kidney transplantation.
This finding is in line with a previous study showing that the serum RANKL/OPG ratio is the best predictive marker for annual progression of radiological damage [ 14] independent of therapy.
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In accordance to this, in a prospective study where clinical examination, TVS, serum markers, and color Doppler, were evaluated in the preoperative investigation of ovarian tumors, the size of the lesion and the TVS morphologic features were the best predictive markers for malignancy in the premenopausal women, and the morphology and CA-125 for the postmenopausal women [ 22].
Is NMDAR2B methylation a better predictive marker than tumor histology?
These results suggested miR-21-5p as the best putative predictive marker.
Among EGFR, HER2 and HER3, HER2 overexpression was the best single predictive marker, but combinations of two markers provided additional predictive information.
For patients with chronic liver diseases and HCC, AFP was found to be the best single predictive marker with a c-statistic (AUC, area under the curve) of 0.668.
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