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It is an independent adverse prognostic factor and, more importantly, it is currently the best predictive factor for the activity of trastuzumab, an anti-HER2 monoclonal antibody (MoAb), which has revolutionized the treatment of this breast cancer subgroup.
However, the BMD is the best predictive factor for fracture in postmenopausal women, despite the fact that bone geometry and microarchitecture are also site-specific risk factors for osteoporotic fracture (grade A recommendation).
In our model, a history of exacerbation is the best predictive factor for exacerbation, followed by an age over 68.
Seguin et al. suggested that a 5-day cut off in length of hospital stay or between the first operation and repeat laparotomy was the best predictive factor for the presence of MDR bacteria [ 13, 14].
It is important to discern that the results reported on the HAQ affect the QOL significantly and independently [ 37] and in fact, the baseline HAQ score was the best predictive factor for QOL as assessed by the Arthritis Impact Measurement Scales 2 that measures QOL in previous studies [ 38].
4 In our own experience, 12 weeks disease duration was the best predictive factor for reaching disease activity score in 28 joints (DAS28) and/or American College of Rheumatology (ACR) remission, in a tight-aggressive therapeutic approach to early RA. 5 These data have been confirmed in another recent Dutch trial.
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The best predictive factors for the NPPV failure in ARF appear to be the level of FiO2 and PaCO2 on admission or within the first hours after starting NPPV (Table 3).
Histological grade, ER, PR, and HER2 were the best predictive factors for chemotherapy response in breast cancer.
Functional status (Barthel Index) and quality of life (EQ-5D) at hospital discharge are the best predictive factors for full functional recovery at long-term follow-up.
Among the determinants studied in ovarian cancer in vivo, LRP mRNA and the S-phase fraction were the best predictive factors for drug response and most specifically for the activity of cisplatin.
We found that the best predictive factors for the presence of a BRCA1 or BRCA2 mutation are families with at least two cases of breast cancer, at least one of which occuring before the age of 50 (p = 0.0335), and families with a history of both breast and ovarian cancer (p < 0.0001).
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