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Patients, who signed informed consent for the BEST trial automatically took part in the BEST-Participation-study and are referred to as participants throughout this manuscript.
Likewise the BEST-Participation-study found no influence of BMI on participation in an exercise trial.
In the BEST-Participation-study among nonparticipants a larger proportion reported living alone.
Upon informed consent women were included in the BEST-study as well as in the BEST-Participation-study.
Patients, who refused participation in the BEST-study but agreed to fill out the short questionnaire for the BEST-Participation-study, are referred to as nonparticipants.
Thus, information for this BEST-Participation-study was available for 30.4% of all breast cancer patients with adjuvant radiotherapy during the study period.
The present BEST-Participation-study was carried out from July 2011 to December 2011 during the patient screening for the BEST-study.
The BEST-Participation-study was an observational study embedded in the BEST-study, collecting information on factors potentially influencing willingness to participate in a randomized exercise-intervention trial.
Protocols of the BEST- and of the BEST-Participation-study were approved by the Ethic Committee of the University of Heidelberg and have been performed in accordance with the ethical standards of the Declaration of Helsinki.
A limitation of our BEST-Participation-study is, that as most of the clinical studies, we also cannot report on the exact percentage of contacted patients with respect to the entire target population.
Due to organizational difficulties in the recruitment process, such as short-term alterations of the medical staff or time constraints of the physicians, not all patients were informed about the BEST-study, and among patients not willing to participate in BEST, not all were asked to complete the questionnaires of the BEST-Participation-study.
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