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If you're going for dramatic truth, it turns out, you're best off putting your cast through the same hell as their characters: constant rain; isolation from the rest of humanity; nature in its rawest state.
Cells initiating growth in newly repleted medium under favorable conditions are best off putting their energy into other processes and reducing stress-response transcripts, again regardless of the repleted nutrient.
Pointing users to Google may seem counterintuitive for a company focused on protecting personal data, but eliminating user choice in such a Big Brother-like fashion under the guise of knowing what's best is off-putting, as well.
One Labour strategist said: "Cameron will be sharp and slick and therefore may appear to come off best but may be rather off-putting.
And after Sex and the City 2, a rotting, racist corpse of a movie, the idea of another slick yet vacuous HBO adaptation is off-putting at best.
Though the story is true, its sanitized feel is off-putting at best.
They are usually off-putting at best, and at worst move people to a point of anger.
But the idea that Austin has been central to the development of a cuisine that has been common in the Latino parts of Texas for decades is off-putting at best.
That's a real benefit even for a guest (and I'd by no means put Duca in this camp) who Tucker has quite evidently bested through a variety of off-putting, rudely dismissive "interviewing" techniques.
You're definitely smart if you're in AP Biology in grade 9, but acting like you're the best just because of that is off-putting.
It was an off-putting performance, to put it mildly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com