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Despite other "non-apoptotic" cellular responses emanating from its signaling, the major and best known function of Fas is apoptosis.
The best known function of p53 is its action as a transcription factor.
The best known function of peptidases is the conversion of bioactive peptides.
As a member of the IAP family, the best known function of survivin is to protect the cells from undergoing apoptosis.
Perhaps the best known function of the miRNA pathway is to control the cell fate through the regulation of transcription factor coding genes.
The best known function of GPIbα is its interaction with von Willebrand Factor (VWF) at sites of vascular injury and, thus, the initialization of primary hemostasis.
Similar(51)
The best known functions of tau are the stabilization of microtubules and the regulation of axonal transport [ 43, 44].
One of the best known functions of the zinc-finger transcription factor Snail is to induce epithelial-to-mesenchymal transition (EMT).
Though one of the best known functions of leptin is regulation of feeding behavior, leptin also plays essential roles in the regulation of cerebral blood flow and metabolism, cell differentiation, cognition and learning, and neurodegeneration, where it may play dual roles in stroke or epilepsy.
In spite of the best known function they have as chaperonin, Hsp are also important players in the control of the immune response, being target by Hsp-specific T cells and antibodies in healthy subjects and also in chronic-inflammatory processes including autoimmune diseases [6], [27], [28], [29].
Although their best known functions are related to the biotransformation of arachidonic acid metabolites, these isoforms are also active in detoxification [ 30, 78].
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Justyna Jupowicz-Kozak
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