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The number of our cases, ∼120 extremely old individuals per population, is not as large as what we see in the best human studies.
Because even the best human studies cannot definitively establish causality and because lead policies have been surrounded by controversies [for an overview, see Moore (2003)], animal models are especially important.
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Given that they are derived from models of mechanical ventilation, the candidate genes advocated by Grigoryev and colleagues seem to be best applied to human studies of response to mechanical ventilation, perpetuation of lung injury, and/or outcomes in patients with ALI.
However, an earlier and possibly best human pathological condition studied was schizophrenia [ 30].
To the best of our knowledge, no human studies have yet been performed.
Those scientists who have recognized TNF antagonism for this indication as a "compelling therapeutic strategy"[ 107] are exactly in line with the guidance to "translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care" that is the published consensus recommendation of world stroke leaders [ 125].
In several human studies, Tregs were best characterized as CD4+CD25hi T-cells expressing the forkhead box transcription factor (FOXP3), which suppress T cell activation and regulate various immune reactions in vitro and in vivo [6] [8].
That plan is "inspired by the best human surgical practices," they wrote in the study.
To the best of our knowledge, there are no longitudinal human studies that have investigated mercury exposure and diabetes risk.
Animal and human studies have been conducted to identify the best ways to treat and manage NP [ 14– 20].
Human studies using GLP-1R agonists have provided the best support for the dependence of GLP-1R activity on glucose concentrations.
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