Although the currently employed model organisms for parturition and preterm birth have their benefits, perhaps the best model for human parturition and preterm birth is humans themselves.
In addition, EB-TS cells are capable of differentiation to both villous and extravillous trophoblast lineages, but without the genotype and phenotype changes associated with transformation, making these cells the best model for human early placental development.
Goto-Kakizaki (GK) rat, a spontaneous non insulin dependent diabetes model with a heterogeneous background, is recognized as one of the best model for human T2DM.
Studies show that the extrapolation of CYP2E1 between species appears to be quite well, and rat seems to be best model for human in this respect [ 27].
We found that the best risk assessment model for human WNV cases included surveillance data from avian, mosquito, and climate sources.
The IFNα/βBP has been shown to contribute to poxvirus pathogenesis in VACV infections (18, 19), and more recently this has been confirmed using the mousepox model, considered the best surrogate mouse model for human smallpox.
Because many different model systems (including amniotes such as the chick and pig) orient their asymmetry without the benefit of cilia (Levin and Palmer, 2007; Spéder et al., 2007; Gros et al., 2009), it is unclear which species is the best model for human disease-relevant symmetry breaking.
Although dogs are commonly affected by diabetic hyperglycemia and are considered the best animal model for the study of human diabetes [ 23], there are few studies examining the effect of glucose on neutrophil oxidative metabolism and apoptosis in dogs.
