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A second generation of sequencing projects culminated in the creation of the second best functionally annotated yeast genome.
Taking the highest scoring match to RP will, on the whole, give an answer to both questions as the source organism in the target database is known and RP most of the time contains the best functionally characterized sequences.
For this model, the woman is best functionally described as a network of nine tissue compartments perfused by blood circulation.
Furthermore, we introduce for the first time a measure of the semantic similarity of the mapped interactions and show that L-GRAAL also uncovers best functionally conserved interactions.
The best functionally characterized AMPs are bactericidal, whereas the properties of antifungal AMPs and their mode-of-action are less well studied.
HECT ligases were among the first family of E3 enzymes to be cloned, and are the best functionally characterized among the thioester-forming E3s (Huibregtse et al., 1995; Scheffner et al., 1995).
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A second observation is that the insertion is best described functionally as an Asp346a insertion.
Second, as measured by the average semantic similarity of the mapped proteins, we observe that L-GRAAL best uncovers functionally conserved proteins.
We assess the biological quality of the protein mappings using the semantic similarity of their Gene Ontology annotations and observe that L-GRAAL best uncovers functionally conserved proteins.
Relevant pairwise comparison scores are listed in figure 4. It is worthwhile trying to determine the phylogenetic relationships between the Syt genes of mammals and those of other animals because it is the rodent Syt proteins which are best characterised functionally.
Referentiality appears to be functional rather than intentional (Cheney and Seyfarth 1990; Hauser 1996), and the best interpretation of functionally referential calls remains disputed (e.g. Owren and Rendall 1997).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com