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The best fitting model with two QTL was tested against the best model fitting only one QTL using an F-test.
The best fitting model with a χ of 1.09 yielded a good fit to the experimental data.
Full modelling analysis of all genotyped variants showed the best fitting model with rare DPYD variants, the number of functional USF-binding sites in the 5′-UTR of TYMS, and the TYMS 3′-UTR deletion (full results shown in Supplementary Materials).
A two-class model was the best fitting model with a high comorbidity and a low comorbidity class.
A change in SCR was observed for all 4 health facilities in Same (Table 3) but was not observed for any of those in Korogwe region (Figures 4c & 4d)(Similar analysis was conducted on pilot survey data which showed the best fitting model with a single conversion rate).
For ALT, ALB, BILIRB, TPROT, TGLOB, AST and ALP, the ACE model – ascribing the total phenotypic variance to additive genetic, common and unique environments – was the best fitting model with narrow-sense heritabilities ranging from 15% in the case of TPROT to 48% in the case of ALP.
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Several sensitivity analyses with different mix of covariates were conducted and the best fitting models with the highest R-square values were presented in this study.
With the best fitting model (GTR+I+Γ with four rate catagories) an iterative procedure described in Swofford et al.[ 64] was used to converge on the best fitting model parameters.
Polynomial regressions were then done to compare linear to non-linear relationships using a step-up approach to find the best fitting model, starting with linear (x1) and ending with x8 polynomial.
Time-dependent covariates were used when non proportional hazards were detected, where the best-fitting model with time-varying risk coefficients are found by maximizing the partial likelihood.
In particular, suppose you take the best-fitting model with fixed bounds (constant SAT) and make a plot of the model results identical to that in Figure 1B.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com