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Finally, Gaussian mixture analysis confirmed a best fitting model of two normal components (detailed in Table 1) in the whole sample of 515 BD patients (216 males and 299 females), which included 12 subjects with BD NOS (Fig. 4).
Using the lower cut-point, the best fitting model of twin resemblance only included additive genetics and unique environment, with a heritability of 45%.
We developed a master model that includes the best fitting model of Hao et al. (2007) as well as a set of other candidate models.
Because the MP and ME phylogenies did not differ significantly according to an SH test (Δ-lnL = 112.3, P = 0. 124), we estimated the best fitting model of Gp-9 nucleotide evolution from the better resolved ME tree using the program MODELTEST [67].
We will subject the best fitting model of the DAS-A to reliability and validity analyses.
The best fitting model of sequence evolution was determined using Modeltest (Posada and Crandall 1998).
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In this case of cross-validation, for K parameter the best-fitting model of semivariogram models is the exponential with a 0.00220342 standardized mean errors for K.
The best-fitting model of evolution (Additional file 3: Table S3) was selected under Akaike information criterion test (Akaike 1974) as implemented in MrModeltest 2.2 (Nylander 2004).
The best-fitting model of the source parameters (M o, f c, t g * ) was obtained by iteration from a starting model using the simplex algorithm (Nelder and Mead 1965; Caceci and Cacheris 1984, Numerical Recipes 1998, Chap. 10.4).
We used the ProtTest server [60] to estimate the best-fitting model of amino acid substitution for each alignment using the Bayesian information criterion (BIC [61]).
For both ML and BA, the best-fitting model of evolution was applied, as determined by Modelgenerator V.85 following the Hierarchical Likelihood Ratio Test (with four discrete gamma categories).
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