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Phylogenetic trees for proteins were obtained using the PHYML [ 57] with the best evolutionary model found in PROTTEST.
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The Akaike Information Criterion in Modeltest [43] was used to find, the best evolutionary model given the data.
Considering the Bayesian information criterion (BIC) and Akaike information criterion (AIC) [ 47], the Tamura 3-parameter model (T92 model) [ 48] was found to be the best evolutionary model for the CAL sequence.
Identification of the best evolutionary model is performed via the AIC approach (see above).
The best evolutionary model for each of the sequenced genes were the six parameter general time reversible (GTR) model of nucleotide substitution (nst = 6, rates = invgamma).
The best evolutionary model for sequences derived from each patient included a class allowing for positively selected codons (ω>1) in 18 of the 22 analyzed patients (Table 3).
The best evolutionary model was also determined with MEGA5.
In all cases the best evolutionary model was estimated to be JTT + G (data not show).
The best evolutionary model estimated by jModelTest 0.1.1 for our data was TrN+I+G.
The best evolutionary model for the ML analysis was selected by the ProtTest [ 52].
The best evolutionary model determined for the sequences was TrN + I + G.
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