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Nevertheless, authors came to the same conclusion as us, namely that infliximab 5 mg/kg at 0, 2, 6 weeks was the best efficacious therapy [OR 6.53 (95 % CI 3.35, 11.61)] compared to placebo [ 31].
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Similar rankings are displayed in Table 3, which reveals that diclofenac-potassium and eletriptan has the best efficacy whereas naratriptan and almotriptan are the least efficacious medications.
Research on how best to deliver efficacious public health strategies in heterogeneous community and organizational contexts remains limited.
The two approved drugs for treating influenza are slickly marketed and extensively prescribed but more than a decade of experience shows that they are modestly efficacious at best.
Indeed, the human immune system itself can safely be assumed to be the best in generating highly efficacious antibodies and these antibodies are most likely superior to those generated from mice or using phage display.
CyA is fast acting and efficacious, but best used in 3- to 4-month courses, due to its many drug interactions and association with nephrotoxicity, hypertension, and possibly lymphoma.
One can only hope that the issues raised – namely what is actually the minimum effective dose, how best to administer possibly partially efficacious doses to reduce the burden of disease, and how to improve vaccine yield – will better prepare us in our ongoing battle with this very old enemy.
DP, a newer ACT regimen, was the most efficacious and best-tolerated regimen in this study.
9 We also assessed the probability that each treatment was the most efficacious regimen, the second best, the third best and so on.
Trials are ongoing to address the best sequence of the most efficacious combination chemotherapy to be given either before or after preoperative chemoradiotherapy.
However, further investigation is needed to establish how this treatment contributes to neutropenia and which doses of each compound are best tolerated while still remaining efficacious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com